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Anti-AXIN2 (C-term) Antibody
Catalog #: 102-16492
Rabbit Anti-Human AXIN2 (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q9Y2T1 |
| Gene Id | 8313 |
| Gene Symbols | AXIN2 |
| Protein Name / Synonyms | AXIN2 (C-term) |
| Clonality | Polyclonal |
| Preparation | This AXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2. |
| Concentration (lot specific) | 0.500 mg/ml |
| Recommended Applications | Western Blotting, IHC-P, FC |
| Research Area | Cardiovascular Disease, Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Specificity
Predicted Reactivity
Mouse, Rat
Other Names
AXIN2; Axin-2; Axin-like protein; Axis inhibition protein 2; Conductin
NCBI Accession #
NP_004646.3
Other Accession #
O70240; O88566; NP_004646.3
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
93558
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100; FC: 1:10-50
 | AXIN2 Antibody (C-term)(Cat# 102-16492) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the AXIN2 antibody detected the AXIN2 protein (arrow). |
 | AXIN2 Antibody (C-term) (Cat# 102-16492) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AXIN2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | AXIN2 Antibody (C-term) (Cat# 102-16492) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.