Anti-BACE1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P56817
Gene Id	23621
Gene Symbols	BACE1
Protein Name / Synonyms	BACE1 (N-term)
Clonality	Polyclonal
Preparation	This BACE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-70 amino acids from the N-terminal region of human BACE1.
Concentration (lot specific)	2.000 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.

Specificity

Predicted Reactivity

Rat, Bovine

Other Names

BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; Beta-site amyloid precursor protein cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2

NCBI Accession #

NP_001193978.1;NP_036236.1;NP_620427.1;NP_620428.1;NP_620429.1

Other Accession #

P56819; P56818; Q2HJ40

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

55711

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of anti-BACE1 Antibody (N-term) (Cat# 102-17615) in mouse heart tissue lysates (35ug/lane). BACE1(arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products