Anti-BAI1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	O14514
Gene Id	575
Gene Symbols	BAI1
Protein Name / Synonyms	BAI1 (C-term)
Clonality	Polyclonal
Preparation	This BAI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1537-1567 amino acids from the C-terminal region of human BAI1.
Concentration (lot specific)	0.320 mg/ml
Recommended Applications	Western Blotting, IHC-P, FC
Research Area	Angiogenesis
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.

Specificity

Other Names

BAI1; Brain-specific angiogenesis inhibitor 1

NCBI Accession #

NP_001693.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

173501

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; FC: 1:10-50

	BAI1 Antibody (Q1552) (Cat# 102-17848) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the BAI1 antibody detected the BAI1 protein (arrow).
	BAI1 Antibody (Q1552) (Cat# 102-17848) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the BAI1 antibody detected the BAI1 protein (arrow).
	BAI1 antibody (C-term) (Cat# 102-17848)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BAI1 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	BAI1 Antibody (C-term) (Cat# 102-17848) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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