B-cell lymphoma 2 (Bcl-2) is the member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. The two isoforms of Bcl-2, isoform 1, also known as 1G5M, and isoform 2, also known as 1G5O/1GJH, exhibit similar fold. However, results in the ability of these isoforms to bind to the BADand BAK proteins, as well as in the structural topology and electrostatic potential of the binding groove, suggest differences in antiapoptotic activity for the two isoforms. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins to the outer mitochondrial and other intracellular membranes.

The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.

This antibody was selected for its ability to specifically detect Bcl-2 from humans. There is no crossreactivity with Caspase-3, Caspase-8 or Livin.