Anti-Bi-Phospho-MET/HGFR (Y1234/Y1235) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Accession Number	P08581
Gene Id	4233
Gene Symbols	MET
Protein Name / Synonyms	Bi-Phospho-MET/HGFR(Y1234/Y1235)
Clonality	Monoclonal
Preparation	This monoclonal antibody is generated from mice immunized with a KLH conjugated synthetic peptide corresponding to sequences in Tyr1234/1235 region of human Met and residues both Tyr1234 and Tyr1235 are phosphorylated.
Concentration (lot specific)	0.450 mg/ml
Recommended Applications	Western Blotting
Research Area	Cancer, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.

Specificity

Other Names

MET; Hepatocyte growth factor receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; Tyrosine-protein kinase Met

NCBI Accession #

NP_000236.2;NP_001120972.1

Format

Type

Purified Phospho-specific Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

155541

Recommended Dilutions

WB: 1:100-500

Detection of endogenous Met in HepG2 cell line. 10 ug/lane of HepG2 cell lysate was used to examine the expression of human Met. Lanes 1-5 represent RayBiotech's different anti-Met monoclonal antibodies that are Cat# 102-10002 through 102-10006. Lane 6 represents auto-phosohorylated-Met in HepG2 cell line detected by anti-phospho-Met Mab (Cat# 102-10001).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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