Anti-BMPR1A (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P36894
Gene Id	657
Gene Symbols	BMPR1A
Protein Name / Synonyms	BMPR1A (N-term)
Clonality	Polyclonal
Preparation	This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BMPR1A.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, FC
Research Area	Angiogenesis, Cardiovascular Disease, Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPRIA binds BMP4 with high-affinity in solution and is a potent BMP-4 antagonist in vitro. In adult tissues, BMPRIA is widely expressed, with the highest expression levels detected in skeletal muscle. BMPRIA is also widely expressed during embryogenesis.

Specificity

Other Names

BMPR1A; ACVRLK3; ALK3; Bone morphogenetic protein receptor type-1A; Activin receptor-like kinase 3; Serine/threonine-protein kinase receptor R5; CD_antigen=CD292; Flags: Precursor

NCBI Accession #

NP_004320.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

60198

Recommended Dilutions

WB: 1:1000; FC: 1:10-50

	The anti-BMPR1A Pab (Cat# 102-14526) is used in Western blot to detect BMPR1A in mouse muscle tissue lysate (Lane 1) and Hela cell lysate (Lane 2).
	Flow cytometric analysis of WiDr cells using BMPR1A Antibody (N-term) (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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