Rabbit Anti-C-rel (NFkB) (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | Q04864 |
| Gene Id | 5966 |
| Gene Symbols | REL |
| Protein Name / Synonyms | C-rel (NFkB) (C-term) |
| Clonality | Polyclonal |
| Preparation | This C-rel (NFkB) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-619 amino acids from the C-terminal region of human C-rel (NFkB). |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Inflammation, NFkB Signaling |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
Nuclear factor (NF)-kappa B is a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NF-kB regulates the expression of a wide variety of genes that involved in apoptosis, viral life cycle, tumorigenesis, autoimmune diseases and inflammation. NF-kB is a heterodimer of members of the rel family of proteins such as p50, p65, and c-rel. In most cells, inhibitory IkB proteins sequester NF-kB/Rel in the cytoplasm. Cellular stimulation precipitates degradation of IkB and modification of NF-kB/Rel proteins, permitting translocation of NF-kB/Rel (c-Rel and RelA) to the nucleus for action on target genes. The important role of c-Rel in B-cell development, growth, and survival has been intensively studied, as well as its function in differentiation and lymphopoiesis (particularly lymphoid cancer).
Specificity
Other Names
REL; Proto-oncogene c-Rel
NCBI Accession #
NP_002899.1
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
68520
Recommended Dilutions
WB: 1:1000
 | Western blot analysis of lysate from Daudi cell line, using C-rel (NFkB)-G601 Antibody(Cat# 102-16753). 102-16753 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug. |
 | Western blot analysis of anti-C-rel (NFkB) Pab (102-16753)in Jurkat (left) and mouse kidney (right) cell line lysate. C-rel (NFkB)(arrow) was detected using the purified Pab. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.
