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ISO 13485:2016 cGMP
Anti-C3c Antibody
Catalog #: DS-MB-00151
Mouse Anti-Human C3c
Product Description
Specifications
| Size | 0.1 mg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | This product recognizes 135kDa complement component 3c (C3c), present in blood serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. |
| Host Species | Mouse |
| Protein Name / Synonyms | C3c |
| Concentration (lot specific) | IgG concentration 1.0mg/ml |
| Recommended Applications | Immunohistology - Frozen, ELISA, Flow Cytometry, Western Blotting |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Storage/Stability
Store at +4 °C or at -20 °C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Borate buffered saline
Format Type:
Purified
Preparation
Immunogen:
Human C3 from normal serum, highly purified by chromatography.
Preservative:
| 0.09% | Sodium Azide (NaN3) |
Expiration:
12 months from the date of shipment when stored properly.