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Anti-CACNA2D2 (Center) Antibody
Catalog #: 102-11990
Rabbit Anti-Mouse CACNA2D2 (Center) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Mouse |
| Host Species | Rabbit |
| Accession Number | Q9NY47 |
| Gene Id | 9254 |
| Gene Symbols | CACNA2D2 |
| Protein Name / Synonyms | CACNA2D2 (Center) |
| Clonality | Polyclonal |
| Preparation | This CACNA2D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-671 amino acids from the Central region of human CACNA2D2. |
| Concentration (lot specific) | 0.360 mg/ml |
| Recommended Applications | Western Blotting, IHC-P, IF |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
Specificity
Other Names
CACNA2D2; KIAA0558; Voltage-dependent calcium channel subunit alpha-2/delta-2; Voltage-gated calcium channel subunit alpha-2/delta-2; Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2
NCBI Accession #
NP_001005505.1;NP_001167522.1;NP_006021.2
Other Accession #
NP_001167522.1; NP_001005505.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
129817
Recommended Dilutions
IF: 1:10-50; WB: 1:1000; IHC: 1:10-50
 | Fluorescent image of U251 cell stained with CACNA2D2 Antibody (Center)(Cat# 102-11990).U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CACNA2D2 primary antibody (1:25, 1 h at 37°). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°).CACNA2D2 immunoreactivity is localized to Cytoplasm significantly. |
 | CACNA2D2 Antibody (Center) (Cat# 102-11990) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CACNA2D2 antibody detected the CACNA2D2 protein (arrow). |
 | CACNA2D2 Antibody (Center) (Cat# 102-11990)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CACNA2D2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.