The neuropeptide, Cocaine and Amphetamine Regulated Transcript (CART), was identified as an mRNA that changed in response to psychostimulant drug administration and injection of CART peptides into the ventral tegmental area produces psychostimulant-like effects. CART encodes for a protein which has an important role in the regulation of appetite and body weight. CART localizes to areas of the central and peripheral nervous systems and is involved in feeding behavior when injected centrally. Expression of CART in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety.

The rabbit anti-human CART antibody detects specifically target derived from human recombinant protein at various concentrations. Cross reactivity with mouse and rat are expected from sequence similarity.

Store at -20°C, if not intended for use within a month, Keep it at 4°C and minimize freezing and thawing when use.