Anti-CASP10 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q92851
Gene Id	843
Gene Symbols	CASP10
Protein Name / Synonyms	CASP10 (Center)
Clonality	Polyclonal
Preparation	This CASP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-192 amino acids from the Central region of human CASP10.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Research Area	Apoptosis, Cancer, Autoimmune Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

CASP10 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in the protein are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.

Specificity

Other Names

CASP10; MCH4; Caspase-10; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; ICE-like apoptotic protease 4; Caspase-10 subunit p23/17; Caspase-10 subunit p12

NCBI Accession #

NP_001193453.1;NP_001193471.1;NP_001221.2;NP_116756.2;NP_116758.1;NP_116759.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

58951

Recommended Dilutions

WB: 1:1000

Western blot analysis of CASP10 antibody (Center) (Cat# 102-11941) in HepG2 cell line lysates (35ug/lane). CASP10 (arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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