Anti-CASP3 Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P42574
Gene Id	836
Gene Symbols	CASP3
Protein Name / Synonyms	CASP3
Clonality	Monoclonal
Preparation	Purified His-tagged CASP3 protein was used to produced this monoclonal antibody.
Concentration (lot specific)	0.390 mg/ml
Recommended Applications	Western Blotting
Research Area	Apoptosis, Cancer, Inflammation, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Specificity

Other Names

CASP3;CPP32; Caspase-3; Caspase-3; Apopain; Caspase-3; Cysteine protease CPP32; Caspase-3; Protein Yama; Caspase-3; SREBP cleavage activity 1; Caspase-3 subunit p17; Caspase-3 subunit p12

NCBI Accession #

NP_004337.2;NP_116786.1

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

31608

Recommended Dilutions

WB: 1:2000

CASP3 Antibody (Cat# 102-10466) western blot analysis in Jurkat,Ramos cell line lysates (35ug/lane).This demonstrates the CASP3 antibody detected the CASP3 protein (arrow).

Antigen Source

Human

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products