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Anti-CCND1 (C-term T286) Antibody
Catalog #: 102-14746
Rabbit Anti-Human CCND1 (C-term T286) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P24385 |
| Gene Id | 595 |
| Gene Symbols | CCND1 |
| Protein Name / Synonyms | CCND1 (C-term T286) |
| Clonality | Polyclonal |
| Preparation | This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-292 amino acids from the C-terminal region of human CCND1. |
| Concentration (lot specific) | 0.430 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Specificity
Predicted Reactivity
Bovine
Other Names
CCND1;BCL1; PRAD1; G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; G1/S-specific cyclin-D1; BCL-1 oncogene; G1/S-specific cyclin-D1; PRAD1 oncogene
NCBI Accession #
NP_444284.1
Other Accession #
Q2KI22
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
33729
Recommended Dilutions
WB: 1:1000
 | CCND1 Antibody (T286) (Cat# 102-14746) western blot analysis in A431,mouse L929,rat C6 cell line lysates (35ug/lane).This demonstrates the CCND1 antibody detected the CCND1 protein (arrow). |
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.