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Anti-CCND1 (C-term T288) Antibody
Catalog #: 102-14511
Rabbit Anti-Human CCND1 (C-term T288) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P24385 |
| Gene Id | 595 |
| Gene Symbols | CCND1 |
| Protein Name / Synonyms | CCND1 (C-term T288) |
| Clonality | Polyclonal |
| Preparation | This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-294 amino acids from the C-terminal region of human CCND1. |
| Concentration (lot specific) | 0.480 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Specificity
Other Names
CCND1; BCL1; PRAD1; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1 oncogene; PRAD1 oncogene
NCBI Accession #
NP_444284.1
Other Accession #
NP_444284.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
33729
Recommended Dilutions
WB: 1:1000
 | CCND1 Antibody (T288) (Cat# 102-14511) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CCND1 antibody detected the CCND1 protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.