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Anti-CCND1-Y226 Antibody
Catalog #: 102-16464
Rabbit Anti-Human CCND1-Y226 Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P24385 |
| Gene Id | 595 |
| Gene Symbols | CCND1 |
| Protein Name / Synonyms | CCND1-Y226 |
| Clonality | Polyclonal |
| Preparation | This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 203-238 amino acids from human CCND1. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, IF |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.
Specificity
Other Names
CCND1; BCL1; PRAD1; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1 oncogene; PRAD1 oncogene
NCBI Accession #
NP_444284.1
Other Accession #
NP_444284
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
33729
Recommended Dilutions
WB: 1:1000; IF: 1:10-50
 | CCND1-Y226 antibody (Cat# 102-16464) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CCND1 antibody detected the CCND1 protein (arrow). |
 | Confocal immunofluorescent analysis of CCND1-Y226 Antibody(Cat# 102-16464) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.