Anti-CCRL1 Antibody

Product Description

Specifications

Size	100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q9NPB9
Gene Id	51554
Gene Symbols	ACKR4
Protein Name / Synonyms	Atypical chemokine receptor 4, C-C chemokine receptor type 11, C-C CKR-11, CC-CKR-11, CCR-11, CC chemokine receptor-like 1, CCRL1, CCX CKR, ACKR4, CCBP2, CCR11, CCRL1, VSHK1
Clonality	Polyclonal
Recommended Applications	Western Blotting, IF
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.

Other Information

Antigen Type

Synthetic Peptide

Images

WB ( 1:500)

Western blot analysis of lysates from HepG2,K562 cell line (from left to right),using CCRL1 Antibody(102-25686). 102-25686 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.

IF (1:100)

Immunofluorescence analysis of COS-7 cells, using CCRL1 antibody.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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