This product was clustered at the Fourth International Workshop on Leukocyte Differentiation Antigen (code number N221) as recognising the CD18 antigen.

The CD18 antigen is an integral membrane glycoprotein of 95kD molecular weight - known as the b chain, of the LFA-1 complex. The CD18 antigen is non-covalently linked to CD11a, b, c molecules.

The main cellular reactivity of this antibody is a strong reactivity with leukocytes (platelets negative).

The CD18 molecule is the receptor for ICAM-1 and is thus important for cell adhesion. This antibody blocks homotypic adhesion and other lymphocyte functions which involve the LFA-1 antigen.