This product recognizes human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. This antibody recognizes an epitope in the alpha subunits of CD221, demonstrated by Western blotting, see Li, S.L. et al. for details.

CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.

The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. This product is reported to partically block binding of IGF-I and IGF-II to CD221, see Li, S.L. et al for details.

CD221