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Anti-CD33 Antibody, PE
Catalog #: 188-10038-PE
Mouse anti-Human CD33 Antibody [PE Conjugated]
Product Description
Specifications
| Size | 100 tests |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not known |
| Host Species | Mouse |
| Accession Number | P20138 |
| Gene Id | 945 |
| Gene Symbols | CD33,SIGLEC3 |
| Protein Name / Synonyms | Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33) |
| Immunogen | Human AML cells were used as the immunogen for this CD33 antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 500 ul at 0.1 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | FACS: 5ul/test/10^6 cells in 0.1ml IF: 1:50-1:100 |
| Domain / Region / Terminus | Cell surface |
| Research Area | Cancer, Adaptive Immunity |
| Shipping Type | Blue ice |
| Storage | 2-8°C |
Description
Description
This antibody recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
Storage
Store the CD33 antibody at 2-8°C. The conjugate is light-sensitive, protect from light.
Expiration:
12 months from the date of shipment when stored properly.