Anti-CD44 Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P16070
Gene Id	960
Gene Symbols	CD44
Protein Name / Synonyms	CD44
Clonality	Monoclonal
Preparation	This CD44 monoclonal antibody is generated from mouse immunized with CD44 recombinant protein.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting, IHC-P, IF, FC
Research Area	Inflammation, Adaptive Immunity
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

Specificity

Other Names

CD44; LHR; MDU2; MDU3; MIC4; CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; CD_antigen=CD44; Flags: Precursor

NCBI Accession #

NP_000601.3;NP_001001389.1;NP_001001390.1;NP_001001391.1;NP_001001392.1;NP_001189484.1;NP_001189485.1;NP_001189486.1

Other Accession #

NP_000601.3

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

81538

Recommended Dilutions

WB: 1:100-500; IHC: 1:10-50; IF: 1:10-50; FC: 1:10-50

	CD44 antibody (Cat# 102-10131) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CD44 antibody detected the CD44 protein (arrow).
	CD44 antibody (Cat# 102-10131) immunohistochemistry analysis in formalin fixed and paraffin embedded human esophagus carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CD44 antibody for immunohistochemistry. Clinical relevance has not been evaluated.
	CD44 antibody (Cat# 102-10131) confocal immunofluorescent analysis with hela cell. 0.01 mg/ml primary antibody was followed by PE-conjugated goat anti-mouse lgG (whole molecule). PE emits red fluorescence. DAPI was used to stain the cell nuclear (blue).
	CD44 Antibody (Cat# 102-10131) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).PE-conjugated goat-anti-mouse secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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