Anti-CD46 (Center Y354) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P15529
Gene Id	4179
Gene Symbols	CD46
Protein Name / Synonyms	CD46 (Center Y354)
Clonality	Polyclonal
Preparation	This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.
Concentration (lot specific)	0.360 mg/ml
Recommended Applications	Western Blotting
Research Area	Adaptive Immunity
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Specificity

Other Names

CD46;Membrane cofactor protein

NCBI Accession #

NP_002380.3;NP_722548.1;NP_758860.1;NP_758861.1;NP_758862.1;NP_758863.1;NP_758869.1;NP_758871.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

43747

Recommended Dilutions

WB: 1:1000

CD46 Antibody (Y354) (Cat# 102-14865) western blot analysis in A549,Hela cell line lysates (35ug/lane).This demonstrates the CD46 antibody detected the CD46 protein (arrow).

Antigen Source

Human

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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