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Anti-CD63 Antibody, PE
Catalog #: 188-10045-PE
Mouse anti-Human/Mouse CD63 Antibody [PE Conjugated]
Product Description
Specifications
| Size | 100 tests |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Specificity | Other species not known |
| Host Species | Mouse |
| Accession Number | P08962 |
| Gene Id | 967 |
| Gene Symbols | CD63,MLA1,TSPAN30 |
| Protein Name / Synonyms | CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) |
| Immunogen | The smooth plasma membrane fraction of MeWo cells was used as the immunogen for this CD63 antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G purified antibody |
| Concentration (lot specific) | 500 ul at 0.1 mg/ml in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | Flow Cytometry: 5ul/test/million cells or 5ul/test/100ul of whole blood Immunofluorescence: 1:50-1:100 for 30 minutes at RT |
| Domain / Region / Terminus | Cytoplasmic |
| Research Area | Adaptive Immunity |
| Shipping Type | Blue ice |
| Storage | 2-8°C |
Description
Description
The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Storage
Store the CD63 antibody at 2-8°C. Conjugate is light sensitive, store in the dark.
Expiration:
12 months from the date of shipment when stored properly.