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Anti-CD8 Antibody (alpha chain), Sodium Azide Free
Catalog #: 188-11225-SAF
Rabbit anti-Human Recombinant CD8 Antibody (alpha chain) [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not known |
| Host Species | Rabbit |
| Accession Number | P01732 |
| Gene Id | 925 |
| Gene Symbols | CD8A,MAL |
| Protein Name / Synonyms | T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a) |
| Immunogen | Recombinant full-length human CD8a protein was used as immunogen for this recombinant CD8 antibody. |
| Isotype | IgG, Kappa |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | Flow Cytometry: 0.5-1ug/million cells Immunofluorescence: 0.5-1ug/ml IHC (FFPE): 0.5-1ug/ml for 30 min at RT |
| Domain / Region / Terminus | Cell surface |
| Research Area | Adaptive Immunity |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
Storage
Store the recombinant CD8 antibody (with azide) at 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
Expiration:
12 months from the date of shipment when stored properly.