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Anti-CDKN1C (N-term) Antibody
Catalog #: 102-10868
Rabbit Anti-CDKN1C (N-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P49918 |
| Gene Id | 1028 |
| Gene Symbols | CDKN1C |
| Protein Name / Synonyms | CDKN1C (N-term) |
| Clonality | Polyclonal |
| Preparation | This CDKN1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-64 amino acids from the N-terminal region of human CDKN1C. |
| Concentration (lot specific) | 0.300 mg/ml |
| Recommended Applications | IF, Western Blotting |
| Research Area | Cancer |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.
Specificity
Other Names
CDKN1C; KIP2; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; p57Kip2
NCBI Accession #
NP_000067.1;NP_001116102.1;NP_001116103.1
Other Accession #
NP_001116102.1; NP_000067.1; NP_001116103.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
32177
Recommended Dilutions
IF: 1:10-50; WB: 1:1000
 | Fluorescent image of A549 cell stained with CDKN1C Antibody (N-term)(Cat# 102-10868).A549 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with CDKN1C primary antibody (1:25, 1 h at 37°). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°).CDKN1C immunoreactivity is localized to Nucleus significantly. |
 | CDKN1C Antibody (N-term) (Cat# 102-10868) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the CDKN1C antibody detected the CDKN1C protein (arrow). |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.