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Anti-CDKN2C (C-term) Antibody
Catalog #: 102-10873
Rabbit Anti-Human CDKN2C (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P42773 |
| Gene Id | 1031 |
| Gene Symbols | CDKN2C |
| Protein Name / Synonyms | CDKN2C (C-term) |
| Clonality | Polyclonal |
| Preparation | This CDKN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-139 amino acids from the C-terminal region of human CDKN2C. |
| Concentration (lot specific) | 0.270 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
Specificity
Other Names
CDKN2C; CDKN6; Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
NCBI Accession #
NP_001253.1;NP_523240.1
Other Accession #
NP_001253.1; NP_523240.1
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
18127
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of CDKN2C (arrow) using rabbit polyclonal CDKN2C Antibody (C-term) (Cat# 102-10873). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CDKN2C gene. |
 | CDKN2C Antibody (C-term) (Cat# 102-10873) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CDKN2C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.