Anti-CENTG1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q99490
Gene Id	116986
Gene Symbols	AGAP2
Protein Name / Synonyms	CENTG1 (C-term)
Clonality	Polyclonal
Preparation	This CENTG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1.
Concentration (lot specific)	0.250 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Specificity

Predicted Reactivity

Rat

Other Names

AGAP2; CENTG1; KIAA0167; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; Centaurin-gamma-1; GTP-binding and GTPase-activating protein 2; Phosphatidylinositol 3-kinase enhancer

NCBI Accession #

NP_001116244.1;NP_055585.1

Other Accession #

Q8CGU4; Q3UHD9; NP_001116244.1; NP_055585.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

124674

Recommended Dilutions

WB: 1:1000

CENTG1 Antibody (C-term) (Cat# 102-10869) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the CENTG1 antibody detected the CENTG1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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