Anti-CERK (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q8TCT0
Gene Id	64781
Gene Symbols	CERK
Protein Name / Synonyms	CERK (C-term)
Clonality	Polyclonal
Preparation	This CERK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 487-516 amino acids from the C-terminal region of human CERK.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Research Area	MAPK Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Ceramide kinases convert the sphingolipid metabolite ceramide into ceramide-1-phosphate, both key mediators of cellular apoptosis and survival. Ceramide metabolism plays an essential role in the viability of neuronal cells, the membranes of which are particularly rich in sphingolipids. CERK catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. This enzyme acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8 dihydroceramide), and to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. High level expression is noted in heart, brain, skeletal muscle, kidney and liver; moderate expression in peripheral blood leukocytes and thymus; and low expression in spleen, small intestine, placenta and lung.

Specificity

Other Names

CERK; KIAA1646; Ceramide kinase; Acylsphingosine kinase; Lipid kinase 4

NCBI Accession #

NP_073603.2

Other Accession #

NP_073603

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

59977

Recommended Dilutions

WB: 1:1000

The anti-CERK Pab (Cat# 102-17120) is used in Western blot to detect CERK in mouse heart tissue lysate (Lane 1) and A2058 cell lysate (Lane 2).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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