Anti-CHK1 (S280) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	O14757
Gene Id	1111
Gene Symbols	CHEK1
Protein Name / Synonyms	CHK1 (S280)
Clonality	Polyclonal
Preparation	This CHK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-287 amino acids from human CHK1.
Concentration (lot specific)	0.420 mg/ml
Recommended Applications	Western Blotting
Research Area	DNA Damage
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

Specificity

Other Names

CHEK1; CHK1; Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1

NCBI Accession #

NP_001107593.1;NP_001107594.1;NP_001231775.1;NP_001265.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

54434

Recommended Dilutions

WB: 1:1000

Chk1 Antibody (S280) (Cat# 102-15013) western blot analysis in Hela cell line and mouse thymus tissue lysates (35ug/lane).This demonstrates the Chk1 antibody detected the Chk1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

Featured Products