Anti-CHRNA3 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P32297
Gene Id	1136
Gene Symbols	CHRNA3
Protein Name / Synonyms	CHRNA3 (N-term)
Clonality	Polyclonal
Preparation	This CHRNA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-52 amino acids from the N-terminal region of human CHRNA3.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.

Specificity

Predicted Reactivity

Bovine

Other Names

CHRNA3; NACHRA3; Neuronal acetylcholine receptor subunit alpha-3

NCBI Accession #

NP_000734.2;NP_001160166.1

Other Accession #

Q07263

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

57480

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of CHRNA3 Antibody (N-term) (Cat# 102-16035) in CEM cell line lysates (35ug/lane).CHRNA3 (arrow) was detected using the purified Pab.
	CHRNA3 Antibody (N-term) (Cat# 102-16035) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CHRNA3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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