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Anti-cIAP-2 Antibody, Biotinylated
Catalog #: 130-10031B-50
Rabbit anti-cIAP-2 Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q13489 |
| Gene Id | 330 |
| Gene Symbols | BIRC3 API2 MIHC RNF49 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was a synthetic peptide derived from human cIAP2. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1: 80, 000(at least detecting 12.5 µg/ml)) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Research Area | Cancer, Inflammation |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
cIAP2 is a member of the Inhibitor of Apoptosis family that inhibit apoptosis by interfering with the activation of caspases. Apoptosis is triggered by a variety of stimuli including members of the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants encoding the same isoform have been identified.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody can specifically bind to its immunogen and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat cIAP2 has not yet been tested.
Related Products
Human cIAP-2 ELISA Kit (cat# ELH-cIAP2-001)RayBio® Human Apoptosis Antibody Array 1 (cat#AAH-APO-1 or AAH-APO-G1)
References
- Seidelin JB, et al..(2007) Upregulation of cIAP2 in regenerating colonocytes in ulcerative colitis. Virchows Arch. 451(6):1031-8.
- Runnebaum IB , et al.. (2005) Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 11(17):6325-32.
Expiration:
12 months from the date of shipment when stored properly.