Anti-COCH (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O43405
Gene Id	1690
Gene Symbols	COCH
Protein Name / Synonyms	COCH (C-term)
Clonality	Polyclonal
Preparation	This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 492-520 amino acids from the C-terminal region of human COCH.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq].

Specificity

Predicted Reactivity

Bovine

Other Names

COCH; COCH5B2; Cochlin; COCH-5B2

NCBI Accession #

NP_001128530.1;NP_004077.1

Other Accession #

Q5EA64; NP_004077.1; NP_001128530.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

59483

Recommended Dilutions

WB: 1:1000

	COCH Antibody (C-term) (Cat# 102-11052) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the COCH antibody detected the COCH protein (arrow).
	Western blot analysis of COCH (arrow) using rabbit polyclonal COCH Antibody (C-term) (Cat# 102-11052). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COCH gene.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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