Anti-COMT (N-term) (Ascites) Antibody

Product Description

Specifications

Size	0.1 mL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	P21964
Gene Id	1312
Gene Symbols	COMT
Protein Name / Synonyms	COMT (N-term) (Ascites)
Clonality	Monoclonal
Preparation	This COMT antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human COMT.
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.

Specificity

Other Names

COMT; Catechol O-methyltransferase

NCBI Accession #

NP_000745.1;NP_001128633.1;NP_001128634.1;NP_009294.1

Other Accession #

NP_000745.1

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

30037

Recommended Dilutions

WB: 1:100-400

COMT Antibody (N-term)(Ascites)(Cat# 102-10381) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the COMT antibody detected the COMT protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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