Anti-Connexin 31 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O75712
Gene Id	2707
Gene Symbols	GJB3
Protein Name / Synonyms	Connexin 31 (C-term)
Clonality	Polyclonal
Preparation	This Connexin 31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human Connexin 31.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

Specificity

Other Names

GJB3; CX31; Gap junction beta-3 protein; Connexin-31

NCBI Accession #

NP_001005752.1;NP_076872.1

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

30818

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	Western blot analysis of hGJB3-C241 (Cat# 102-12786) in WiDr cell line lysates (35ug/lane). GJB3 (arrow) was detected using the purified Pab.(2ug/ml)
	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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