Rabbit Anti-Connexin 50 (C-term) Antibody, 400 ul
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Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse |
| Host Species | Rabbit |
| Accession Number | P48165 |
| Gene Id | 2703 |
| Gene Symbols | GJA8 |
| Protein Name / Synonyms | Connexin 50 (C-term) |
| Clonality | Polyclonal |
| Preparation | This Connexin 50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-433 amino acids from the C-terminal region of human Connexin 50. |
| Concentration (lot specific) | 1.430 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Introduction
GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. This particular connexin only forms junctional channels. GJA8 is expressed in the eye lens, and defects in GJA8 are the cause of zonular pulverulent cataract type 1 (CZP1), a form of autosomal dominant congenital cataract.
Specificity
Predicted Reactivity
Chicken
Other Names
GJA8; Gap junction alpha-8 protein; Connexin-50; Lens fiber protein MP70
NCBI Accession #
NP_005258.2
Other Accession #
P36381
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
48229
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of anti-GJA8 Antibody (C-term) (Cat# 102-12794) in mouse kidney tissue lysates (35ug/lane). GJA8 (arrow) was detected using the purified Pab. |
 | Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.