Anti-Cortactin (Ascites) Antibody

Product Description

Specifications

Size	0.1 mL
Estimated Lead Time	1-2 weeks
Species	Human
Accession Number	Q14247
Gene Id	2017
Gene Symbols	CTTN
Protein Name / Synonyms	Cortactin(Ascites)
Clonality	Monoclonal
Preparation	Purified His-tagged Cortactin protein(Fragment) was used to produced this monoclonal antibody.
Recommended Applications	Western Blotting
Research Area	Cytoskeletal Reorganization
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Specificity

Other Names

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

NCBI Accession #

NP_001171669.1;NP_005222.2;NP_612632.1

Other Accession #

NP_005222.2

Format

Type

Mouse Monoclonal Antibody (Mab)

Calculated Molecular Weight (Da)

61586

Recommended Dilutions

WB: 1:1000-8000

Cortactin Antibody (Cat# 102-10231) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the Cortactin antibody detected the Cortactin protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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