Anti-Creatine Kinase B (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P12277
Gene Id	1152
Gene Symbols	CKB
Protein Name / Synonyms	Creatine Kinase B (C-term)
Clonality	Polyclonal
Preparation	This Creatine Kinase B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-270 amino acids from the C-terminal region of human Creatine Kinase B.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Research Area	Phosphorylation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Creatine Kinase (CK) is a dimeric enzyme composed of either M- or B-type subunits. The resulting isoenzymes are expressed at varying levels in different tissues. CK-BB, a cytoplasmic predominantly found in brain tissues, participates in energy homeostasis, reversibly catalyzing the transfer of a phosphate group between ATP and target proteins such as a creatine phosphate. CK-BB exists in normally neglible amounts in the serum of adults, overexpression of CK-BB is associated with cancers of the breast, ovary, prostate, colon, and in small-cell lung cancer. Global assessment of changes in serum levels of CK-BB, CK-MB and CK-MM, are used as a marker for myocardial infarction.

Specificity

Other Names

CKB; CKBB; Creatine kinase B-type; B-CK; Creatine kinase B chain

NCBI Accession #

NP_001814.2

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

42644

Recommended Dilutions

WB: 1:1000

	Western blot analysis of CKB (arrow) using rabbit polyclonal CKB-C254 (Cat# 102-17105). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CKB gene.
	The anti-CKB Pab (Cat# 102-17105) is used in Western blot to detect CKB in Y79 cell lysate (Lane 1) and mouse colon tissue lysate (Lane 2).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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