Description
C-reactive protein(CRP) belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. CRP is synthesized by the liver in response to factors released by fat cells (adipocytes).Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.
CRP is used mainly as a marker of inflammation. Apart from liver failure, there are few known factors that interfere with CRP production. Measuring and charting CRP values can prove useful in determining disease progress or the effectiveness of treatments. Blood, usually collected in a serum-separating tube, is analysed in a medical laboratory or at the point of care. Various analytical methods are available for CRP determination, such as ELISA, immunoturbidimetry, rapid immunodiffusion, and visual agglutination.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat C-reactive protein has not yet been tested.
Related Products
RayBio® Human Cytokine Antibody Array 7(Cat# AAH-CYT-7-2) Adiponectin EIA Kit(Cat#EIA-ACRP-1)
References
- Dehghan A; et.al., (2007). Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes 56 (3): 8728.
- St-Onge, et.al.,(2009). Baseline serum C-reactive protein is associated with lipid responses to low-fat and high-polyunsaturated fat diets. J Nutr 139 (4): 6803.
Expiration:
12 months from the date of shipment when stored properly.