Anti-CSH1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P01243
Gene Id	1443
Gene Symbols	CSH1
Protein Name / Synonyms	CSH1 (C-term)
Clonality	Polyclonal
Preparation	This CSH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-204 amino acids from the C-terminal region of human CSH1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq].

Specificity

Other Names

CSH1; Chorionic somatomammotropin hormone; Lactogen; Placental lactogen

NCBI Accession #

NP_001308.1;NP_066271.1

Other Accession #

P01241; P01242; Q14406; NP_001308.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

25020

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100

	CSH1 Antibody (C-term) (Cat# 102-10859) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the CSH1 antibody detected the CSH1 protein (arrow).
	Western blot analysis of CSH1 (arrow) using rabbit polyclonal CSH1 Antibody (C-term) (Cat# 102-10859). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CSH1 gene.
	CSH1 Antibody (C-term) (Cat# 102-10859) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CSH1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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