Anti-CSTB (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P04080
Gene Id	1476
Gene Symbols	CSTB
Protein Name / Synonyms	CSTB (Center)
Clonality	Polyclonal
Preparation	This CSTB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the Central region of human CSTB.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).

Specificity

Predicted Reactivity

Bovine

Other Names

CSTB; CST6; STFB; Cystatin-B; CPI-B; Liver thiol proteinase inhibitor; Stefin-B

NCBI Accession #

NP_000091.1

Other Accession #

P35478; P25417; NP_000091.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

11140

Recommended Dilutions

WB: 1:1000

CSTB Antibody (Center) (Cat# 102-12447) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the CSTB antibody detected the CSTB protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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