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Anti-CT1 Antibody
Catalog #: 130-10032
Rabbit Anti-Human CT1 Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Specificity | The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat Cardiotrophin-1 has not yet been tested. |
| Accession Number | Q16619 |
| Gene Id | 1489 |
| Gene Symbols | CTF1 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from Human CT-1. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CGLYREWLSRTEGDLGQLLPGGSA |
| Recommended Applications | ELISA (recommended work dilution= 1: 40, 000(at least detecting 25ng/ml)) |
| Reconstitution | Supplied as lyophilized and purified antibody originally containing PBS, without Preservative Stabilizers, such as Sodium Azide. The final concentration is indicated on the shipping vial. The antibody is stable for at least years from the data of receipt when stored at -20°C to -70°C. Reconstituted antibody (recommended with H20 1 mg/ml) can also be aliquoted and stored frozen at -20°C to -70°C in a manual defrost freezer for months without detectable loss activity. Upon reconstitution, the antibody can also be stored over months at 4°C. Please avoid freeze-thaw cycles. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Cardiotrophin-1 (CT-1) is a cardiac hypertrophic factor and belongs to the IL-6 cytokine family. The protein interacts with the glycoprotein 130/leukemia inhibitory factor receptor beta heterodimer. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice. In addition, CT-1 enhances transcription factor NF kappa B DNA-binding activities and activates phosphatidylinositol 3-kinase in cardiac myocytes. It is also highly expressed in the heart, prostate, skeletal muscle, and ovary, and expressed at the lower levels in lung, kidney, pancreas, thymus, small intestine, and testis. CT-1 is highly secreted by myotubes, and promotes the survival of cultured embryonic mouse and rat MNs. CT-1 is associated with pathophysiology of heart diseases, like hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.
Typical Data
Storage/Stability
Store at -20°C, if not intended for use within a month, keep it at 4°C and minimize freezing and thawing when use.
Expiration
12 months from the date of shipment when stored properly.
References
- Ronald W, et al.Cardiotrophin-1, a muscle-derived Cytokine, is required for the survival of subpopulations of developing motoneurons. J Neurosci. 2001. 21:1283-1291.
- Arce V, et al.Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique. J Neurosci Res. 1999. 55:119-126.