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Anti-CT1 Antibody, Biotinylated
Catalog #: 130-10032B-50
Rabbit anti-CT1 Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q16619 |
| Gene Id | 1489 |
| Gene Symbols | CTF1 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was synthetic peptide derived from Human CT-1. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Immunogen Sequence | CGLYREWLSRTEGDLGQLLPGGSA |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1: 40, 000(at least detecting 25 µg/ml)) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Cardiotrophin-1 (CT-1) is a cardiac hypertrophic factor and belongs to the IL-6 cytokine family. The protein interacts with the glycoprotein 130/leukemia inhibitory factor receptor beta heterodimer. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice. In addition, CT-1 enhances transcription factor NF kappa B DNA-binding activities and activates phosphatidylinositol 3-kinase in cardiac myocytes. It is also highly expressed in the heart, prostate, skeletal muscle, and ovary, and expressed at the lower levels in lung, kidney, pancreas, thymus, small intestine, and testis. CT-1 is highly secreted by myotubes, and promotes the survival of cultured embryonic mouse and rat MNs. CT-1 is associated with pathophysiology of heart diseases, like hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody can specifically bind to its immunogen, and did not show any cross reactivity with unrelated antigens in ELISA. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse and rat Cardiotrophin-1 has not yet been tested.
Related Products
Human Cardiotrophin-1 (CT-1) ELISA Kit (Cat# ELH-CT1-001 )Recombinant Human Cardiotrophin-1 (Cat# 230-00008 )
References
- Ronald W, et al.Cardiotrophin-1, a muscle-derived Cytokine, is required for the survival of subpopulations of developing motoneurons. J Neurosci. 2001. 21:1283-1291.
- Arce V, et al.Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique. J Neurosci Res. 1999. 55:119-126.
Expiration:
12 months from the date of shipment when stored properly.