Anti-CTNNB1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P35222
Gene Id	1499
Gene Symbols	CTNNB1
Protein Name / Synonyms	CTNNB1(C-term)
Clonality	Polyclonal
Preparation	This CTNNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-751 amino acids from the C-terminal region of human CTNNB1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Angiogenesis, Cardiovascular Disease, Cancer, Wnt-beta-Catenin Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Specificity

Predicted Reactivity

Mouse, Rat, Bovine

Other Names

CTNNB1; CTNNB; Catenin beta-1; Beta-catenin

NCBI Accession #

NP_001091679.1;NP_001091680.1;NP_001895.1

Other Accession #

Q9WU82; Q02248; Q0VCX4; NP_001091679.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

85497

Recommended Dilutions

WB: 1:1000

CTNNB1 Antibody (C-term) (Cat# 102-14325) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the CTNNB1 antibody detected the CTNNB1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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