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Anti-CTNNB1 (N-term) Antibody
Catalog #: 102-14653
Rabbit Anti-Human CTNNB1 (N-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P35222 |
| Gene Id | 1499 |
| Gene Symbols | CTNNB1 |
| Protein Name / Synonyms | CTNNB1 (N-term) |
| Clonality | Polyclonal |
| Preparation | This CTNNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 amino acids from the N-terminal region of human CTNNB1. |
| Concentration (lot specific) | 1.400 mg/ml |
| Recommended Applications | Western Blotting |
| Research Area | Angiogenesis, Cardiovascular Disease, Cancer, Wnt-beta-Catenin Signaling |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2.
Specificity
Predicted Reactivity
Mouse, Rat, Bovine, Xenopus
Other Names
CTNNB1;CTNNB; Catenin beta-1; Catenin beta-1; Beta-catenin
NCBI Accession #
NP_001091679.1;NP_001091680.1;NP_001895.1
Other Accession #
P26233; Q9WU82; Q02248; Q0VCX4
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
85497
Recommended Dilutions
WB: 1:1000
 | Western blot analysis of CTNNB1 Antibody (N-term) Pab (Cat# 102-14653) pre-incubated without(lane 1) and with(lane 2) blocking peptide in human placenta tissue lysate. CTNNB1 Antibody (N-term) (arrow) was detected using the purified Pab. |
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.