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Anti-CTSK (Center R222) Antibody
Catalog #: 102-17314
Rabbit Anti-Human CTSK (Center R222) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P43235 |
| Gene Id | 1513 |
| Gene Symbols | CTSK |
| Protein Name / Synonyms | CTSK (Center R222) |
| Clonality | Polyclonal |
| Preparation | This CTSK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-237 amino acids from the Central region of human CTSK. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, FC |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.
Specificity
Predicted Reactivity
Bovine, Pig, Monkey, Rabbit
Other Names
CTSK; CTSO; CTSO2; Cathepsin K; Cathepsin O; Cathepsin O2; Cathepsin X
NCBI Accession #
NP_000387.1
Other Accession #
P43236; Q9GLE3; P61276; Q5E968
Format
Type
Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
36966
Recommended Dilutions
IHC: 1:10-50; FC: 1:10-50; WB: 1:1000
 | Formalin-fixed and paraffin-embedded human breast carcinoma with CTSK Antibody (Center R222), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
 | Flow cytometric analysis of ZR-75-1 cells using CTSK Antibody (Center R222)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
 | Western blot analysis of CTSK (arrow) using rabbit polyclonal CTSK Antibody (Center R222) (Cat# 102-17314). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CTSK gene (Lane 2) . |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.