Anti-CTTN (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q14247
Gene Id	2017
Gene Symbols	CTTN
Protein Name / Synonyms	CTTN (Center)
Clonality	Polyclonal
Preparation	This CTTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the Central region of human CTTN.
Concentration (lot specific)	0.460 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.

Specificity

Predicted Reactivity

Chicken

Other Names

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

NCBI Accession #

NP_001171669.1;NP_005222.2;NP_612632.1

Other Accession #

Q01406; NP_005222.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

61586

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	CTTN Antibody (Center) (Cat# 102-12125) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CTTN antibody detected the CTTN protein (arrow).
	Western blot analysis of CTTN (arrow) using rabbit polyclonal CTTN Antibody (Center) (Cat# 102-12125). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CTTN gene.
	CTTN Antibody (Center) (Cat# 102-12125)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CTTN Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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