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Anti-Cyclin D2 Antibody
Catalog #: 102-26466
Mouse Anti-Cyclin D2 Antibody, 100 µl
Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Mouse |
| Accession Number | P30279 |
| Gene Id | 894 |
| Gene Symbols | CCND2 |
| Protein Name / Synonyms | CCND 2;CCND2;CCND2_HUMAN;CyclinD2;G1/S specific cyclin D2;G1/S-specific cyclin- |
| Clonality | Monoclonal |
| Recommended Applications | Western Blotting |
| Research Area | Cell Cycle |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Other Information
Antigen Type
Recombinant Protein
Images
WB (1:1000)
Western blot detection of Cyclin D2 in CHO-K1 cell lysate?A?and CHO-K1 transfected by Cyclin D2-fragment EGFP fusion protein?B?cell lysate using Cyclin D2 mouse mAb (1:1000 diluted).Predicted band size:38KDa.Observed band size:38KDa.
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.