Anti-CYP17A1 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P05093
Gene Id	1586
Gene Symbols	CYP17A1
Protein Name / Synonyms	CYP17A1 (Center)
Clonality	Polyclonal
Preparation	This CYP17A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-388 amino acids from the Central region of human CYP17A1.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	IF, Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

CYP17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in CYP17A1 gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.

Specificity

Predicted Reactivity

Monkey

Other Names

CYP17A1; CYP17; S17AH; Steroid 17-alpha-hydroxylase/17,20 lyase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Steroid 17-alpha-monooxygenase

NCBI Accession #

NP_000093.1

Other Accession #

Q2XVA1

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

57371

Recommended Dilutions

IF: 1:10-50; WB: 1:1000

	Confocal immunofluorescent analysis of CYP17A1 Antibody (Center) (Cat# 102-17677) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
	Western blot analysis of anti-CYP17A1 Antibody (Center)(Cat# 102-17677) in K562 cell line lysates (35ug/lane). CYP17A1(arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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