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Anti-DCX (S128) Antibody
Catalog #: 102-15130
Rabbit Anti-Human DCX (S128) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | O43602 |
| Gene Id | 1641 |
| Gene Symbols | DCX |
| Protein Name / Synonyms | DCX (S128) |
| Clonality | Polyclonal |
| Preparation | This DCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-137 amino acids from human DCX. |
| Concentration (lot specific) | 0.410 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
Specificity
Predicted Reactivity
Mouse, Rat
Other Names
DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X
NCBI Accession #
NP_000546.2;NP_835364.1;NP_835365.1;NP_835366.1
Other Accession #
Q9ESI7; O88809
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
49318
Recommended Dilutions
WB: 1:1000; IHC: 1:10-50
 | Western blot analysis of lysate from human brain tissue lysate, using Phospho-DCX-S128. ctrl(Cat# 102-15130). 102-15130 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane. |
 | Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with DCX Antibody (S128) (Cat# 102-15130), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.