Anti-DHH (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O43323
Gene Id	50846
Gene Symbols	DHH
Protein Name / Synonyms	DHH (Center)
Clonality	Polyclonal
Preparation	This DHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human DHH.
Concentration (lot specific)	0.500 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.

Specificity

Predicted Reactivity

Mouse

Other Names

DHH; Desert hedgehog protein; HHG-3; Desert hedgehog protein N-product; Desert hedgehog protein C-product

NCBI Accession #

NP_066382.1

Other Accession #

Q61488; NP_066382.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

43577

Recommended Dilutions

WB: 1:1000

DHH Antibody (Center) (Cat# 102-14168) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the DHH antibody detected the DHH protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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