Anti-DJ-1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	Q99497
Gene Id	11315
Gene Symbols	PARK7
Protein Name / Synonyms	DJ-1 (N-term)
Clonality	Polyclonal
Preparation	This DJ-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DJ-1.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IF
Research Area	Inflammation, Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Park 7 acts as positive regulator of androgen receptor-dependent transcription, and may function as redox-sensitive chaperone and as sensor for oxidative stress, as well as preventing aggregation of SNCA. This protein has been shown to protect neurons against oxidative stress and cell death, and to play a role in fertilization. Park7 is detected in tau inclusions in brains from neurodegenerative disease patients, and is generally highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart, with detectable levels in placenta, brain, astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa. Defects in Park7 are the cause of autosomal recessive early-onset Parkinson disease 7 (PARK7), a form of Parkinson disease characterized by onset before 40 years, slow progression and initial good response to levodopa.

Specificity

Predicted Reactivity

Zebrafish, Bovine

Other Names

PARK7; Protein DJ-1; Oncogene DJ1; Parkinson disease protein 7

NCBI Accession #

NP_001116849.1;NP_009193.2

Other Accession #

Q99LX0; Q5XJ36; Q5E946

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

19891

Recommended Dilutions

WB: 1:1000; IF: 1:10-50

	Western blot analysis of anti-Park7 (DJ-1) Antibody (N-term) (Cat# 102-16774) in mouse brain,kidney,liver tissue lysates and NIH-3T3, Hela cell line lysates (35ug/lane). Park7 (arrow) was detected using the purified Pab.
	Confocal immunofluorescent analysis of DJ-1 Antibody (N-term)(Cat# 102-16774) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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